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There are additional download of Istio distributions and istioctl binaries for Linux, MacOS and Windows that you can find in this page. We recommend using GetMesh to obtain the required files.
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Like Toby in this episode, Josh and Hrishi go to shul to try and learn more about the death penalty and faith. They have a conversation with Rabbi Jonathan Spira-Savett. Plus, we email Aaron Sorkin to ask how Marlee Matlin came to be cast as Joey Lucas.
This episode of the Dork-O-Motive podcast celebrates the life and times of this amazing America, a man some argue is the greatest hot rodder of all time. The story is told through period stories, period audio, and interviews with guys like Humpy Wheeler, author Samuel Hawley, historian Bret Kepner, and Art's son Tim Arfons. This is one of the most in-depth studies on the life of a man who was so brave and brilliant, you'll be blown away by the end of the show.
The Coup is the 14th episode of Season 1 of Alias. Sydney and Dixon are sent to Las Vegas to gather information from a K-Directorate agent who has ties to the group that attacked and nearly destroyed SD-6. Meanwhile, Sydney learns some shocking news about Francie's fiancé, Charlie, while Will begins his journey in discovering what SD-6 really is, and Jack continues to try to be more of a father to Sydney when he helps her decide whether or not to continue with graduate school.
Meanwhile, David McNeil explains to Will that he installed a back-door program in the software that he developed. Following McNeil's instructions, Will sneaks into the headquarters of the company where McNeil once worked. He is able to recover and download a \"digital guestbook\" of everyone who has been using McNeil's software - the next clue in Will's quest for the truth about SD-6.
Citation: Lemas DJ, Mack JA, Schoch JJ, Cacho N, Plasencia E, Rhoton-Vlasak AS, et al. (2020) Postnatal pediatric systemic antibiotic episodes during the first three years of life are not associated with mode of delivery. PLoS ONE 15(3): e0229861.
Antibiotic episodes were defined as any antibiotic that was administered or prescribed more than 10 days from any prior or subsequent antibiotic prescription, from birth to the last wellness visit on record. Cumulative antibiotic episodes for each child were analyzed as a count variable and shown here as the percentage of infants that were prescribed 0 to 4 or more antibiotic episodes during the first three years.
After adjusting for covariates, there was no statistically significant difference between the number of total antibiotics episodes (p = 0.07). In this line chart, the mean antibiotic episode was estimated over the first three years of life by mode of delivery. Blue represents those infants delivered via cesarean section and the orange represents vaginally delivered infants. Counts of infants according to mode of delivery and postnatal age are listed below the line chart.
The impact of antibiotic exposure and child-maternal health outcomes has largely focused on intrapartum antibiotic prophylaxis (IAP) to reduce neonatal early-onset sepsis (EOS) [41]. As a standard of care, most women receive IAP either for Group B Streptococcus (GBS) colonization during labor[42], or for unknown GBS status during preterm labor. IAP is administered as a form of prophylaxis for infection prior to cesarean delivery[43,44] and for preterm premature rupture of membranes (PPROM) prior or during labor and delivery [45]. Our analysis did not formally address IAP or perinatal antibiotics; however we were able to adjust for early-onset sepsis (EOS) risk factors and excluded children with birth weight < 2500 grams and admission to the neonatal intensive care unit (NICU). Additionally, our analysis likely included infants that were treated with empiric antibiotics for presumed sepsis during the first 48 hours, receiving antibiotics without NICU admission. Previous work has demonstrated 6% of term infants treated with empiric antibiotics for presumed sepsis were exposed to ampicillin and/or gentamicin immediately after birth [46,47]. Additional limitations of this study included limited verification of patient antibiotic compliance and bias associated with lack of follow-up/missing data. EHR data. There is also potential for misclassification of pediatric antibiotic prescriptions and the possibility that children are receiving pediatric care (and antibiotics) outside the UFHealth system. We would anticipate that any misclassification is nondifferential with respect to delivery type, which admittedly would bias comparisons in rates between the delivery groups towards the null. There is also potential for antibiotic episodes calculated from inpatient and outpatient prescriptions to include antibiotics that were prescribed but may not have been taken. As described previously[35,48], we computed antibiotic episodes using a 10-day window and it is possible a different window of time in between antibiotic prescriptions may result in differences by mode of delivery. Notably, we found that two percent of the infants were administered narrow-spectrum and broad-spectrum within the same 10-day window, thus the occurrences of narrow and broad episodes are not mutually exclusive.
Cesarean sections delivery and pediatric antibiotic exposure have each independently been associated with changes in pediatric outcomes such as obesity [49] and asthma [50]. Despite these observations, there is limited population-based data that describes how mode of delivery informs the patterning of postnatal pediatric antibiotic prescriptions. In a large Canadian cohort (n = 251,817) focused on antibiotics and the risk of pediatric asthma, infants that were delivered by CS accounted for 24% of births and 43% of these children were prescribed at least one antibiotic in their first year of life [51]. An analysis of antibiotics and pediatric obesity in 28,354 Danish mother-child dyads revealed that exposure to antibiotics during the first six months of life was the same between children delivered vaginally and children delivered by CS [16]. Our results extend these observations by reporting mode of delivery, in healthy term infants, was not associated with overall antibiotic episodes, narrow-spectrum or broad-spectrum episodes during the first three years of life.
BACKGROUND: It is controversial to what degree α(+)-thalassaemia protects against episodes of uncomplicated malaria and febrile disease due to infections other than Plasmodium. METHODS: In Tanzania, in children aged 6-60 months and height-for-age z-score < -1.5 SD (n = 612), rates of fevers due to malaria and other causes were compared between those with heterozygous or homozygotes α(+)-thalassaemia and those with a normal genotype, using Cox regression models that accounted for multiple events per child. RESULTS: The overall incidence of malaria was 3.0/child-year (1, 572/526 child-years); no differences were found in malaria rates between genotypes (hazard ratios, 95% CI: 0.93, 0.82-1.06 and 0.91, 0.73-1.14 for heterozygotes and homozygotes respectively, adjusted for baseline factors that were predictive for outcome). However, this association strongly depended on age: among children aged 6-17 months, those with α(+)-thalassaemia experienced episodes more frequently than those with a normal genotype (1.30, 1.02-1.65 and 1.15, 0.80-1.65 for heterozygotes and homozygotes respectively), whereas among their peers aged 18-60 months, α(+)-thalassaemia protected against malaria (0.80, 0.68-0.95 and 0.78, 0.60-1.03; p-value for interaction 0.001 and 0.10 for hetero- and homozygotes respectively). No effect was observed on non-malarial febrile episodes. CONCLUSIONS: In this population, the association between α(+)-thalassaemia and malaria depends on age. Our data suggest that protection by α(+)-thalassaemia is conferred by more efficient acquisition of malaria-specific immunity. 1e1e36bf2d